Individualized dose.
Tidomet 100 mg/25 mg tab Patient not previously treated w/ levodopa Initially 1 tab tid, increased gradually in increments of carbidopa 12.5 mg w/ levodopa 50 mg or carbidopa 25 mg w/ levodopa 100 mg daily or on alternate days as necessary. Maintenance: Carbidopa 75-200 mg w/ levodopa 750 mg to 2 g daily in divided doses. Max: Carbidopa 200 mg daily.
Patient previously treated w/ levodopa 1/
4 of dose previously being taken.
Patient taking <1.5 g or >1.5 g levodopa Initially 1 tab tid or qid.
Tidomet 250 mg/25 mg tab Initially 1 tab tid, may be increased by 1 tab/day or every other day as necessary, up to 8 tab/day.
Tidomet CR tab Patient already receiving levodopa therapy & currently receiving levodopa alone Initially 1 tab bid adjusted according to response at intervals of not <3 days.
Patient who are not already receiving initial dose Should not exceed 600 mg daily.
Patient already receiving conventional prep Initially same dose to that of conventional prep but dosing intervals should be prolonged & normally between 4-12 hr. Alter dose & intervals according to response allowing at least 3 days between adjustments. Maintenance: Carbidopa 100 mg w/ levodopa 400 mg to carbidopa 400 mg w/ levodopa 1.6 g.
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